|
KMID : 1234420080360030195
|
|
Korean Journal of Microbiololgy and Biotechnology
2008 Volume.36 No. 3 p.195 ~ p.200
|
|
|
Evaluation of Antimicrobial, Antithrombin, and Antioxidant Activity of Aerial Part of Saxifraga stolonifera
|
|
Sohn Ho-Yong
Ryu Hee-Young
Jang Yu-Jin
Jang Han-Su
Park Yu-Mi
Kim Sa-Youl
|
|
|
Abstract
|
|
|
|
Saxifraga stolonifera (Saxifragaceae) is a perennial herbaceous plant growing in Korea, China, Japan and Russia. The aerial part has been used as herbal medicine for treatment of pneumonia, frostbite, inflammation and microbial infection. In this study, fresh juice and methanol extract were prepared from the aerial part of S. stolonifera, and their antimicrobial, antithrombin, and antioxidant activity were evaluated, respectively. The fresh juice showed weak antimicrobial activity against Proteus vulgaris, Escherichia coli O157:H7 and Candida albicans with ignorable DPPH scavenging activity. But, the methanol extract showed strong antioxidant activity (IC50 of 37.5 ?g/mL) with minor, broad-range antimicrobial activity. Antithrombin activities were not observed in fresh juice and extract, up to 1.5 mg/mL. Sequential organic solvent fractionation of methanol extract showed that IC50s of ethylacetate and the butanol fraction were 6.9 and 7.8 ug/mL, respectively, that is comparable with vitamin C or butylated hydroxytoluene. Analysis of component in extract and fractionates suggested that the antioxidants in fractions are diverse and the active substances have glycosylated phenolic structure. Our results suggest that the aerial part of S. stolonifera could be used as the natural source of potential antioxidant.
|
|
|
KEYWORD
|
|
|
Antimicrobial, antioxidant, antithrombosis, DPPH scavenging activity, Saxifraga stolonifera
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|